Blar i forfatter "Palara, Anthimi"

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    • Mechanism and structural requirements for formation of p62 bodies and degradation of p62 by selective autophagy 

      Palara, Anthimi (Doctoral thesis; Doktorgradsavhandling, 2021-12-03)
      Selective autophagy is responsible for the lysosomal degradation of damaged and surplus cytoplasmic components, including misfolded proteins and dysfunctional organelles. Selective autophagy is required for protein and organelle quality control basally and upon stress. For the autophagic process to be precise, selective autophagy receptors (SARs) like SQSTM1/p62 are required. Autophagic substrates ...

    • Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila 

      Jacomin, Anne-Claire; Petridi, Stavroula; Di Monaco, Marisa; Bhujabal, Zambarlal; Jain, Ashish; Mulakkal, Nitha C.; Palara, Anthimi; Powell, Emma L.; Chung, Bonita; Zampronio, Cleidiane; Jones, Alexandra; Cameron, Alexander; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-26)
      Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood. Here, we show that <i>Drosophila</i> Atg8a protein, homologous to mammalian LC3, interacts with the transcription factor Sequoia in a LIR motif-dependent ...

    • SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components 

      Abudu, Yakubu Princely; Shrestha, Birendra Kumar; Zhang, Wenxin; Palara, Anthimi; Brenne, Hanne Britt; Larsen, Kenneth Bowitz; Wolfson, Deanna; Dumitriu, Gianina; Øie, Cristina Ionica; Ahluwalia, Balpreet Singh; Levy, Gahl; Behrends, Christian; Tooze, Sharon A; Mouilleron, Stephane; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
      Mitophagy is the degradation of surplus or damaged mitochondria by autophagy. In addition to programmed and stress-induced mitophagy, basal mitophagy processes exert organelle quality control. Here, we show that the sorting and assembly machinery (SAM) complex protein SAMM50 interacts directly with ATG8 family proteins and p62/SQSTM1 to act as a receptor for a basal mitophagy of components of the ...

    • Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake 

      Jakobi, Arjen J.; Huber, Stefan T.; Mortensen, Simon A.; Schultz, Sebastian; Palara, Anthimi; Kuhm, Tanja; Shrestha, Birendra Kumar; Lamark, Trond; Hagen, Wim J.H.; Wilmanns, Matthias; Johansen, Terje; Brech, Andreas; Sachse, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
      p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1 domain filament formation in vitro remain to be determined and the role of p62 filaments inside the cell is currently unclear. We here determine four high-resolution cryo-EM structures of different human ...